Product Description

Dosage form and Strength of Adakveo (Crizanlizumab-tmca) Injection:
It is in Injection form.
It is a clear to opalescent, colorless to slightly brownish-yellow solution in a single dose vial.
Each vial contains 100mg/ml (10 mg/ml) of Crizanlizumab-tmca.

Mechanism Of Action of Adakveo (Crizanlizumab-tmca) Injection:
It is a humanized IgG2 kappa monoclonal antibody that binds to P-selectin and blocks interactions with its ligands, including P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab can also dissociate preformed P-selectin /PSGL-1 complex. Binding P-selectin on the surface of the activated endothelium and platelets blocks interactions between endothelial cells, platelets, red blood cells, and leukocytes.

Administration of Adakveo (Crizanlizumab-tmca) Injection:
Administer 5 mg/kg of the drug after dilution by intravenous infusion over a period of 30 minutes on Week 0, Week 2, and every 4 weeks thereafter.
It should be prepared and administered by a healthcare professional.
For Intravenous Infusion after dilution.
Single dose vial.
Discard unused portion.

Therapeutic Use of Adakveo (Crizanlizumab-tmca) Injection:
It is used to reduce the frequency of Vaso occlusive crises in adults and paediatric patients aged 16 years and older with sickle cell disease.

Usage Instruction of Adakveo (Crizanlizumab-tmca) Injection:
For Intravenous Infusion after dilution.
Single dose vial.
Discard unused portion.
Do not self-medicate.
Your doctor may adjust your dose depending as per the need.

Side Effects:
Back pain,
Nausea,
Fever,
Abdominal pain,
Joint pain,
Allergic reactions like rashes, itching sensation or redness,
Headache,
Vomiting,
Dizziness,
Sweating,
Shortness of breath.

Safety Precautions:
Alcohol:
Use of the medication in alcoholic patient may be unsafe. As alcohol is a trigger of sickle cell disease.
Use of alcohol may increase the risk of pain crisis related to sickle cell disease.
However, it is advisable to consult a doctor for personalized advice.

Pregnancy:
The study of the drug in pregnant women is not exactly known.
However, It should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the fetus.
Pregnant women should consult their doctor for appropriate treatment options.

Lactating Mothers:
The study of the drug in lactating mother is not known.
Lactating mothers should seek medical advice for appropriate alternatives.

Driving:
It may affect the ability to drive, so it is recommended to avoid driving after taking the medication.
Consult your doctor for guidance on driving safety.

Renal Impairment:
The study of the drug in Renally Impaired Patient is not known.
Consulting a doctor is crucial for appropriate guidance.

Hepatic Impairment:
The study of the drug in Hepatically Impaired Patient is not known.
However, it is important to consult a doctor for proper evaluation and potential dosage adjustments.

Contraindications:
Known hypersensitivity.

Amari Trade Alliance is an eminent SGS Compliance Wholesaler, Exporter, Distributor, and Supplier. We take pride in providing high-quality Adakveo (Crizanlizumab-tmca) Injection. With our extensive Industry expertise and commitment to compliance, we ensure that our customers receive reliable and authentic pharmaceutical products.

We prioritize accessibility and ensure the supply and availability of Adakveo (Crizanlizumab-tmca) Injection in numerous cities across India. Whether you reside in Delhi, Mumbai, Pune, Hyderabad, Bangalore, Chennai, Kolkata, Lucknow, Nashik, Nagpur, Aurangabad, Mysore, Tripura, Patna, Vijayawada, Kozhikode, Jaipur, Ahmedabad, Agra, Jabalpur, Bhopal, Meerut, Aligarh, Varanasi, Kochi, Madurai, or Coimbatore, we assure to promptly and efficiently serve your needs.

Please note that the price of Adakveo (Crizanlizumab-tmca) Injection may vary across different regions, including the United Arab Emirates, Dubai, Singapore, Turkey, China, Vietnam, Philippines, Myanmar, Thailand, Japan, Sudan, Tanzania, Egypt, Saudi Arabia, Kenya, Brazil, Chile, Iraq, Yemen, Oman, Somalia, Zambia, Zimbabwe, Angola, Nigeria, Ghana, Mauritania, Morocco, Algeria, Colombia, Venezuela, Peru, Bangladesh, Indonesia, Malaysia, South Korea, Australia, Canada, Brazil, various African countries, as well as Belarus, Kazakhstan, Uzbekistan, Armenia, Azerbaijan, Moldova, Tajikistan, Kyrgyzstan, and Turkmenistan.

Select Amari Trade Alliance as your trusted partner for procuring Adakveo (Crizanlizumab-tmca) Injection. Our commitment to quality, compliance, and customer satisfaction sets us apart. For specific pricing and availability information, kindly reach out to us. Our dedicated team will provide you with the necessary details. Contact us today to fulfil your requirements and experience our exceptional service.